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Outcomes of cardiac transplant recipients followed for >2 years. Patients were divided into those who had persistent demonstration of antiendothelial cell antibody (AECA+) posttransplant vs patients who never demonstrated positivity (AECA−) posttransplant. The importance of non-human leukocyte antigen (non-HLA) antibodies directed at endothelial cell targets not present on lymphocytes can cause antibody-mediated rejection (AMR) and graft loss [25]
