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Cedars-Sinai Medical Center protocol for treating antibody-mediated rejection (AMR) that is C4d+. After AMR diagnosis by biopsy, patients are treated with pulse Solumedrol (SM) (10 mg/kg) daily × 3 on day 1 and intravenously administered immunoglobulin (IVIG) 2 g/kg (maximum dose 140 g), followed on day 2 by rituximab 375 mg/m2 . A repeat IVIG dose is usually given at 30–60 days after AMR diagnosis
