Table 1.
Established prostate cancer susceptibility alleles
| dbSNP number | Chromosome | Gene a | Risk allele b | Study |
|---|---|---|---|---|
| rs1465618 | 2p21 | THADA | A | Eeles et al. 2009 [21] |
| rs721048 | 2p15 | EHBP1 | A | Gudmundsson et al. 2008 [27] |
| rs12621278 | 2q31.1 | ITGA6 | A | Eeles et al. 2009 [21] |
| rs4857841 | 3q21.3 | EEFSEC | A | Gudmundsson et al. 2009 [57] |
| rs12500426 | 4q22.3 | PDLIM5 | A | Eeles et al. 2009 [21] |
| rs17021918 | 4q22.3 | PDLIM5 | C | Eeles et al. 2009 [21] |
| rs7679673 | 4q24 | FLJ20032 | C | Eeles et al. 2009 [21] |
| rs9364554 | 6q25.3 | SLC22A3 | T | Eeles et al. 2008 [28] |
| rs10486567 | 7p15.2 | JAZF1 | G | Thomas et al. 2008 [26] |
| rs6465657 | 7q21.3 | LMTK2 | C | Eeles et al. 2008 [28] |
| rs1512268 | 8p21.2 | NKX3-1 | T | Eeles et al. 2009 [21] |
| rs12543663 | 8q24.21 | C | Al Olama et al. 2009 [16] | |
| rs10086908 | 8q24.21 | T | Al Olama et al. 2009 [16] | |
| rs1016343 | 8q24.21 | T | Al Olama et al. 2009 [16] | |
| rs13252298 | 8q24.21 | A | Al Olama et al. 2009 [16] | |
| rs6983561 | 8q24.21 | C | Al Olama et al. 2009 [16] | |
| rs16901979 | 8q24.21 | A | Gudmundsson et al. 2007 [11] | |
| rs16902094 | 8q24.21 | G | Gudmundsson et al. 2009 [57] | |
| rs445114 | 8q24.21 | T | Gudmundsson et al. 2009 [57] | |
| rs620861 | 8q24.21 | C | Al Olama et al. 2009 [16] | |
| rs6983267 | 8q24.21 | G | Al Olama et al. 2009 [16] | |
| rs1447295 | 8q24.21 | A | Amundadottir et al. 2006 [9] | |
| rs10993994 | 10q11.23 | MSMB | T | Eeles et al. 2008 [28] |
| rs4962416 | 10q26.13 | CTBP2 | C | Thomas et al. 2008 [26] |
| rs7127900 | 11p15.5 | A | Eeles et al. 2009 [21] | |
| rs12418451 | 11q13.2 | A | Zheng et al. 2009 [34] | |
| rs11228565 | 11q13.2 | A | Gudmundsson et al. 2009 [57] | |
| rs10896449 | 11q13.2 | G | Thomas et al. 2008 [26] | |
| rs11649743 | 17q12 | HNF1B | G | Sun et al. 2008 [30] |
| rs4430796 | 17q12 | HNF1B | A | Gudmundsson et al. 2007 [11] |
| rs1859962 | 17q24.3 | G | Gudmundsson et al. 2007 [11] | |
| rs8102476 | 19q13.2 | PPP1R14A | C | Gudmundsson et al. 2009 [57] |
| rs2735839 | 19q13.33 | KLK3 | A | Eeles et al. 2008 [28] |
| rs9623117 | 22q13.1 | TNRC6B | C | Sun et al. 2009 [31] |
| rs5759167 | 22q13.2 | BIK | G | Eeles et al. 2009 [21] |
| rs5945619 | Xp11.22 | NUDT11 | C | Eeles et al. 2008 [28] |
aGenes within the linkage-disequilibrium block defined by the associated variant: BIK, BCL2-interacting killer; CTBP2, C-terminal binding protein 2 isoform 2; EEFSEC, elongation factor for selenoprotein translation; EHBP1, EH domain binding protein 1; FLJ20032, hypothetical protein LOC54790; HNF1B, hepatocyte nuclear factor 1 homeobox B; ITGA6, integrin alpha chain 6; JAZF1, juxtaposed with another zinc finger gene 1; KLK3, kallikrein 3; LMTK2, lemur tyrosine kinase 2; MSMB, β-microseminoprotein isoform a precursor; NKX3-1, NK3 transcription factor related locus 1; NUDT11, nudix-type motif 11; PDLIM5, PDZ and LIM domain 5 isoform d; PPP1R14A, protein phosphatase 1 regulatory inhibitor; SLC22A3, solute carrier family 22 member 3; SLC25A37, mitochondrial solute carrier protein; THADA, thyroid adenoma associated isoform 1; TNRC6B, trinucleotide repeat containing 6B isoform 2. bRisk alleles as defined from published data cited in the column.