Table 2.
Echocardiography parameters recorded from conscious WT and CaMKIIδ KO mice
| Parameters | WT (n=40) | KO (n=38) | P values |
|---|---|---|---|
| Heart rate (beat/min) | 675±4 | 689±5 | NS |
| LVIDd (mm) | 3.10±0.02 | 3.04±0.04 | NS |
| LVIDs (mm) | 1.53±0.02 | 1.35±0.03 | <0.01 |
| FS (%) | 50.87±0.57 | 55.77±0.74 | <0.01 |
| WT (n=37) | KO (n=30) | |||
|---|---|---|---|---|
| Parameters | Baseline | ISO (1.5mg/kg) | Baseline | ISO (1.5mg/kg) |
| Heart rate (beat/min) | 675±4 | 689±4* | 687±5 | 614±10* |
| LVIDd (mm) | 3.10±0.03 | 3.00±0.03* | 3.06±0.05 | 2.98±0.06* |
| LVIDs (mm) | 1.53±0.03 | 0.98±0.02* | 1.37±0.03# | 0.95±0.03* |
| FS (%) | 50.81±0.57 | 67.40±0.81* | 55.29±0.66# | 67.96±0.61* |
| Changes of FS (%) | 33.05±1.77 | 23.43±1.90# | ||
| WT (n=9) | KO (n=11) | |||
|---|---|---|---|---|
| Parameters | Baseline | Swimming | Baseline | Swimming |
| Heart rate (beat/min) | 665±10 | 658±8 | 691±12 | 656±11* |
| LVIDd (mm) | 3.14±0.06 | 2.93±0.04* | 3.04±0.07 | 2.81±0.07* |
| LVIDs (mm) | 1.58±0.05 | 1.03±0.02* | 1.29±0.07# | 0.97±0.05* |
| FS (%) | 49.59±1.21 | 64.86±0.82* | 57.66±1.79# | 65.88±1.37* |
| Change of FS (%) | 31.37±3.48 | 14.90±2.88# | ||
*
: p<0.05, compared with baseline;
#
: p<0.05, compared with WT; LVIDd and LVIDs: left ventricular internal dimensions at diastole and systole, respectively; FS: left ventricle fractional shortening; WT: wild type; KO: CaMKIIδ knockout.