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Th2 effector cells and asthma pathogenesis. Th2 cells have a central role in orchestrating the allergen-induced inflammatory response. Th2 derived IL-4 and IL-13 stimulate B cells to synthesise IgE whilst IL-5 is necessary for eosinophilic inflammation. Th2 cytokines are also involved in mast cell proliferation and allergic airway remodelling. Key: Eϕ, eosinophil; EpC, epithelial cell; EMTU, epithelial to mesenchymal tropic unit; ASM, airway smooth muscle; AHR, airway hyperreactivity.
