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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Chem Res Toxicol. 2009 Dec;22(12):1897–1904. doi: 10.1021/tx900043s

Figure 5. Schematic of enzyme-mediated generation of AHR proagonist.

Figure 5

(A) AST catalyzes reaction of L-Trp with α-ketoglutaric acid to form I3P and L-glutamic acid. (B) D-Amino acid oxidase catalyzes deamination of D-Trp in the presence of molecular oxygen and water, to form I3P, ammonia, and hydrogen peroxide.