Serial echocardiography analyses of left ventricular ejection fraction (EF, panel A) and end diastolic volume (LVEDV, panel B) before and after TAC in NTG and KO mice. Serial Echo analysis was performed on NTG and age-matched KO mice at the day before (marked as 0 week after TAC in the graphs) and 2, 6, 8, and 10 weeks after the TAC or sham surgery. Mean ±SE. *: P<0.05 compared with NTG sham; #: P<0.05 compared with KO sham; $: P<0.05 compared with NTG TAC.