Table 1.
Echocardiographic characterization of NTG, TG and KO mice from 10 to 20 weeks of age
| 10 week |
16 week | 20 week |
|||||
|---|---|---|---|---|---|---|---|
| NTG | TG | KO | KO | KO | NTG | TG | |
| n | 36 | 30 | 23 | 12 | 12 | 12 | 12 |
| LVIDd (mm) | 3.79±0.21 | 3.74±0.18 | 3.58±0.28* | 3.84±0.15 | 3.87±0.19 | 3.77±0.18 | 3.72±0.32 |
| LVIDs (mm) | 2.34±0.21 | 2.28±0.20 | 2.26±0.24 | 2.61±0.14* | 2.64±0.17 | 2.40±0.17 | 2.33±0.29 |
| LVPWd (mm) | 0.77±0.10 | 0.76±0.12 | 0.85±0.12* | 0.88±0.09 | 0.90±0.06* | 0.82±0.08 | 0.76±0.07 |
| HR (bpm) | 438±45 | 415±39 | 443±45 | 403±26 | 444±44 | 432±49 | 445±36 |
| FS (%) | 38.4±3.8 | 39.5±4.6 | 37.2±3.6 | 32.2±1.8* | 31.3±1.9* | 37.4±3.5 | 37.3±4.2 |
| EF (%) | 69.2±4.7 | 70.6±5.5 | 68.0±4.7 | 61.1±2.5* | 59.8±2.7* | 68.0±4.2 | 67.9±5.2 |
| EDV (μl) | 61.8±7.9 | 61.2±8.5 | 54.6±9.5* | 65.2±5.5 | 65.5±7.2 | 63.2±7.5 | 61.0±9.7 |
| ESV (μl) | 19.1±4.1 | 17.9±3.8 | 17.6±4.8 | 25.4±3.0* | 26.3±3.3* | 20.2±3.5 | 19.3±5.5 |
LVIDd: Left ventricular internal diameter atthe end of diastole; LVIDs: Left ventricular internal diameter atthe end of systole; LVPWd: Left ventricular posterior wall thickness at the end of diastole; HR: Heart rate in beats per minute; FS: Percentage fractional shortening; EF: Ejection fraction; EDV: LV volume at end-diastole; ESV: LV volume at end-systole; Mean±SD.
*
P<0.05; KO compared to NTG and TG at corresponding age. No statistical significant difference was detected for any of the parameters between NTG and TG at anytime point.