Table 3.

BR-DIM PK parameters after the oral administration of the first dose of BR-DIM on Cycle 1, Day 1

Patient #	Dose (mg)	Tmax (h)	Cmax (ng/ml)	AUC0-t (ng/ml h)	Mean Cmax (CV%) (ng/mL)	Mean AUC0-t (CV%) (ng/mL*h)
1	75	3.0	57	224	42 (32%)	192(16%)
2	75	4.0	34	189
3	75	3.0	34	163
4*	150	3.0	139	638	104(29%)	450 (43%)
5*	150	3.0	87	251
6	150	4.0	87	462
7	225	4.0	241	1231	134 (59%)	599 (70%)
4*	225	4.0	54	374
5*	225	2.0	106	370
8	225	4.0	135	423
9	300	3.0	452	1472	236 (66%)	899 (48%)
10	300	2.0	138	578
11	300	2.0	244	984
12	300	3.0	112	563

^*Patients with intra-patient dose escalation.

Patient ID numbers in Table 3 match those in Figure 2, for the subset of 7 patients shown in Figure 2.