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. 2010 Jun 30;285(34):25875–25879. doi: 10.1074/jbc.C110.150482

FIGURE 2.

FIGURE 2.

Structural representation of EBF3 IPT/TIG and HLHLH domains. A, schematic illustration of EBF domain composition. IPT/TIG and HLHLH domains are depicted in orange and red, respectively. B, schematic representations of the IPT/TIG and HLHLH domain dimer. Coloring for first chain is the continuation of the rainbow from Fig. 1 where the C terminus is in red, and the other chain is represented in cream. the HLHLH region is presented in the dotted diamond. β-Sheet numbering is shown for the IPT/TIG domain. C, the left-hand side is the representation of the IPT/TIG domain indicating the presence of a buried surface area. The right-hand side is a 90° turn (anticlockwise) of one of the monomers, revealing a hydrophobic core (lemon) situated at the interface of the two molecules. D, close-up of HLHLH region shows packing of α-helix 1 (H1) with α-helix 2 (H2) of adjacent monomers in this region. Proline residues present in the loop between H1 and H2 and available for interaction are also shown. TAD, transactivation domain.