Growth phenotype of the mutant mice. A, pedigree of the mutants. B, picture of the fetus and placenta at E18.5. Scale bar, 5 mm. C and D, fetus body weight (C) and placenta weight (D) are represented by the bar chart. Wild-type, n = 9; IG-DMR(−/+), n = 6; Gtl2(+/−), n = 5; and IG-DMR(−/+)/Gtl2(+/−), n = 5. The values are expressed as the means ± S.E. For comparison of the date, statistical analyses were carried out with one-way analysis of variance. The different superscripts denote the statistically differences (p < 0.05) between the genotype. E, the growth curve after birth. Wild-type, n = 11, black; Gtl2(+/−), n = 1, blue; IG-DMR(−/+)/Gtl2(+/−), n = 14, green.