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. 2010 May 28;285(34):26121–26125. doi: 10.1074/jbc.M109.075325

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Gene expression in the Dlk1-Dio3 domain. A, graphical representations of the expression levels of the five imprinted genes Dlk1, Gtl2, Rian, Mirg, and Dio3 at E18.5. The values are expressed as the means ± S.E. Wild-type, n = 4, yellow; IG-DMR^(−/+), n = 4, red; Gtl2^(+/−), n = 3, blue; and IG-DMR^(−/+)/Gtl2^(+/−), n = 5, green. It is normalized to 1 in each tissue, which represents the average expression level of the WT. The expression value of Rian and Mirg in the IG-DMR^(−/+)/Gtl2^(+/−) double mutants was individually indicated by dots because the expression was varied among samples. B, Northern blot analysis of Rtl1 expression at E18.5. B, brain; T, tongue; Lu, lungs; Li, liver; and P, placenta. Glyceraldehyde-3-phosphate dehydrogenase (Gapdh) was used as control. For comparison of the date, statistical analyses were carried out with one-way analysis of variance. The superscripts denote the differences (p < 0.05) between the genotype means. W, wild-type; I, IG-DMR^(−/+); G, Gtl2^(+/−); D, IG-DMR^(−/+)/Gtl2^(+/−).