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. 1972 Sep;51(9):2352–2358. doi: 10.1172/JCI107047

Effect of prostaglandin E1 on certain renal actions of parathyroid hormone

Nama P Beck 1, Frederick R DeRubertis 1, Michael F Michelis 1, Robert D Fusco 1, James B Field 1, Bernard B Davis 1
PMCID: PMC292402  PMID: 4344730

Abstract

Parathyroid hormone increased basal adenyl cyclase activity and that increase was inhibited by prostaglandin E1 (PGE1). Tissue cyclic 3′,5′-adenosine monophosphate (cyclic AMP) concentrations were increased by parathyroid hormone and that increase was likewise inhibited by PGE1. Both parathyroid hormone and dibutyryl cyclic AMP increased 32P incorporation into renal cortical phospholipids. PGE1 diminished the effect of parathyroid hormone but not dibutyryl cyclic AMP to influence that parameter. PGE1 likewise modulated the effect of parathyroid hormone but not dibutyryl cyclic AMP to decrease fractional phosphate reabsorption by the renal tubule. It is suggested that PGE1 inhibits the effect of parathyroid hormone by decreasing its effect on adenyl cyclase. Such interaction may be important in modulating the intracellular action of parathyroid hormone on kidney cortex.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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