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Effect of Zn2+ ions on the single-channel activity of chimera H-2′(RRR→QDA). Representative recordings from cell-attached patches in the absence (A) or presence (B) of 10 μm Zn2+ (in the pipette solution). In both cases, the pipette also contained 1 mm ACh. The closed state level is indicated by c; the open state level is indicated by o. Recordings were performed at −70 mV at room temperature.
