Table 2.
Pemphigus vulgaris | First-line therapy | High-dose corticosteroid |
Second-line therapy | Azathioprine Mycophenolate mofetil IVIG Rituximab |
|
Third-line therapy | Cyclophosphamide Chlorambucil Plasmapheresis Dapsone Gold Cyclosporine |
|
Paraneoplastic pemphigus | First-line therapy | High-dose corticosteroid |
Second-line therapy | Azathioprine Mycophenolate mofetil Cyclosporine |
|
Third-line therapy | High-dose cyclophosphamide IVIG Plasmapheresis/immunopheresis Rituximab Topical tacrolimus |
|
Pemphigus foliaceus | First-line therapy | Systemic corticosteroid |
Second-line therapy | Azathioprine Mycophenolate mofetil |
|
Third-line therapy | Etanercept | |
Bullous pemphigoid | First-line therapy | Systemic corticosteroid Tetracycline/nicotinamide Dapsone |
Second-line therapy | Azathioprine Mycophenolate mofetil Methotrexate IVIG |
|
Dermatitis herpetiformis | First-line therapy | Dapsone Gluten-free diet |
Second-line therapy | Sulfapyridine Tetracycline/nicotinamide Heparin Cyclosporine Colchicine Systemic corticosteroid |
|
Linear IgA dermatosis | First-line therapy | Dapsone |
Second-line therapy | Sulfapyridine Colchicine Tetracycline/nicotinamide Flucloxacillin High-dose IVIG |
|
Pemphigoid gestationis | First-line therapy | Topical or systemic corticosteroid Antihistamine (for pruritus) |
Second-line therapy | Plasmapheresis High-dose IVIG Minocycline/nicotinamide |
|
Epidermolysis bullosa acquisita | First-line therapy | Systemic corticosteroid Azathioprine Dapsone Supportive therapy/avoidance of trauma |
Second-line therapy | Methotrexate Cyclophosphamide Colchicine Cyclosporine |
|
Third-line therapy | Immunoadsorption/rituximab |