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. 2009 May;2(5):19–28.

Table 2.

Management of bullous disorders

Pemphigus vulgaris First-line therapy High-dose corticosteroid
Second-line therapy Azathioprine
Mycophenolate mofetil
IVIG
Rituximab
Third-line therapy Cyclophosphamide
Chlorambucil
Plasmapheresis
Dapsone
Gold
Cyclosporine
Paraneoplastic pemphigus First-line therapy High-dose corticosteroid
Second-line therapy Azathioprine
Mycophenolate mofetil
Cyclosporine
Third-line therapy High-dose cyclophosphamide
IVIG
Plasmapheresis/immunopheresis
Rituximab
Topical tacrolimus
Pemphigus foliaceus First-line therapy Systemic corticosteroid
Second-line therapy Azathioprine
Mycophenolate mofetil
Third-line therapy Etanercept
Bullous pemphigoid First-line therapy Systemic corticosteroid
Tetracycline/nicotinamide
Dapsone
Second-line therapy Azathioprine
Mycophenolate mofetil
Methotrexate
IVIG
Dermatitis herpetiformis First-line therapy Dapsone
Gluten-free diet
Second-line therapy Sulfapyridine
Tetracycline/nicotinamide
Heparin
Cyclosporine
Colchicine
Systemic corticosteroid
Linear IgA dermatosis First-line therapy Dapsone
Second-line therapy Sulfapyridine
Colchicine
Tetracycline/nicotinamide
Flucloxacillin
High-dose IVIG
Pemphigoid gestationis First-line therapy Topical or systemic corticosteroid
Antihistamine (for pruritus)
Second-line therapy Plasmapheresis
High-dose IVIG
Minocycline/nicotinamide
Epidermolysis bullosa acquisita First-line therapy Systemic corticosteroid
Azathioprine
Dapsone
Supportive therapy/avoidance of trauma
Second-line therapy Methotrexate
Cyclophosphamide
Colchicine
Cyclosporine
Third-line therapy Immunoadsorption/rituximab