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Cell adhesion following 7 days of culture in vitro as a function of surface type. The growth of all four human cell types was inhibited by the immobilization of trypsin on PDMS substrates compared to unmodified and non-extracted PDMS. Cellular adhesion of human astrocytes, fibroblasts, endothelial cells, and microglia was significantly lower on trypsin-modified PDMS surfaces when compared with uncoated PDMS (p < 0.0001 for all cell-types).
