Table 1.

Equilibrium dissociation constants for various atypical antipsychotics including asenapine (Asen, aka Org 5222), clozapine (Cloz), olanzapine (Olanz), risperidone (Risp), and sertindole (Sert). Efficacy at dopamine D₂ receptors is shaded given that clinical efficacy of antipsychotics require ~70% D₂ occupancy. Muscarinic effects are boxed given that efficacy at muscarinic receptors have been linked to weight gain/cognitive dysfunction side effects. The typical antipsychotic haloperidol (Halo) is added for comparative purposes.

Equilibrium dissociation constants for antipsychotics at human brain receptors
Asen	5HT2C 0.27	5HT2A 0.77	α1 1.1	D2 2	H1 9.3	5HT1D 10.2	5HT1A 15	α2 16	M 7000
Cloz	5HT2A 2.59	H1 3.1	5HT2C 4.8	α1 6.8	M 9	α2 15	5HT1D 130	5HT1A 160	D2 210
Olanz	H1 0.087	5HT2A 1.48	5HT2C 4.1	D2 20	M 36	α1 44	5HT1D 150	α2 280	5HT1A 610
Risp	5HT2A 0.15	α1 2.7	D2 3.77	5HT1D 3.9	H1 5.2	α2 8	5HT2C 32	5HT1A 190	M 34000
Sert	5HT2A 0.14	D2 2.7	α1 3.9	5HT2C 6	5HT1D 20	α2 190	H1 320	5HT1A 1050	M 5000
Halo	D2 2.6	α1 17	5HT1D 40	5HT2A 61	H1 260	α2 600	5HT1A 1800	5HT2C 4700	M >10000