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. 2010 Aug 6;6:46. doi: 10.1186/1744-8069-6-46

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Copyright ©2010 Westlund et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Knee Joint Temperature Increase is Blocked by ROS Scavenger PBN. Right and left knee joint temperature (°C) at baseline and 4 h after k/c induction of left knee joint inflammation (Arth) in rats pre-treated i.p. with saline (n = 4) or the ROS scavenger, PBN (n = 4). The PBN provided protection from significant increase in knee joint temperature typical of this arthritis model. Temperature increase in both knees is indicative of a centrally mediated "mirror" effect on regional blood flow. Core body temperature measured with a rectal thermometer was not increased over baseline.