Table 1. Values of the standard set of biophysical parameters for regions of the DSGC.
Parameter | Dendrites | Soma | Hillock | Thin Segment | Axon |
Nav1.2 | 0 | 0 | 0 | 0 | 50 |
Nav1.6 | 35 | 4 | 4 | 100 | 0 |
Kdr | 15 | 15 | 15 | 20 | 10 |
KA | 35 | 35 | 35 | 0 | 0 |
KIh | 0 | 0.09 | 0 | 0 | 0 |
sKCa1 | 0.125 | 0.125 | 0.125 | 0 | 0 |
sKCa2 | 0.05 | 0.05 | 0.05 | 0 | 0 |
Ca | 0.0140 | 0.0140 | 0.0140 | 0 | 0 |
Vrev | −0.075 | −0.100 | −0.100 | −0.100 | −0.100 |
Rm | 35000 | 10000 | 10000 | 10000 | 10000 |
The table shows the parameters for the DSGC models that produced matching F/I and phase plots for 5 different morphologies. In the leftmost column, Nav1.2, Nav1.6, Kdr, KA, sKCa1, sKCa2, Ca are channel densities, given in mS/cm2. Vrev is the leak reversal potential (volts), and was treated as a constrained variable when calibrating spike initiation. Rm is membrane (leak) resistance in Ωcm2. For all morphologies except where specified otherwise, Ri = 200 Ωcm.