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. 2010 Aug 19;6(8):e1001051. doi: 10.1371/journal.ppat.1001051

Figure 3. Activation of HCMV and EBV-specific CD8 T cells during acute hepatitis B infection.

Figure 3

A) Frequencies of total, and Influenza, HCMV, EBV specific CD8 T cells expressing CD38/HLA-DR and Ki-67 at the onset of acute hepatitis B. Data shown only for the patients where virus-specific CD8 T cells were visualized (P7, P9, P10–13, P22–28). The numbers in brackets indicate the number of patients tested. P value was calculated using Mann Whitney test. The differences are considered significant when the P value <0.05. B) Phenotypic profile of total CD8 T and EBV-specific (BZLF-1 190–197+ EBNA-3A 193–201) CD8 T cells over time in a representative acute hepatitis B patient (P 12). Percentages of respective gates/upper left quadrants are shown.