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. 2010 Aug 19;6(8):e1001052. doi: 10.1371/journal.ppat.1001052

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Representative images (200×) of colon stained with a polyclonal antibody against E. coli (brown) in SIV early acute infected (4 dpi) and chronically SIV-infected RMs (Non-AIDS and AIDS). Note the small regions of epithelial discontinuities in the SIV⁺ Non-AIDS RMs resulting in luminal E. coli ⁺ content in direct contact with the LP and increased frequency of E. coli ⁺ cells within the LP. Sections from two SIV⁺ AIDS RMs show the range of epithelial damage with associated microbial product infiltration, findings frequently seen in RMs with AIDS. Arrows point to regions of epithelial discontinuities and microbial translocation into the LP.