Table 1. Animals used for study.

Animal ID	Species	Virus	Days post infection	Infection Status	Major Pathologic/Clinical Findings	Opportunistic Infections	pVLa
595	RM	None	Uninfected	-	ND	None	NA
DBM6	RM	None	Uninfected	-	ND	None	NA
34572A	RM	None	Uninfected	-	Pneumoconiosis	None	NA
04D169	RM	None	Uninfected	-	ND	None	NA
P049	RM	None	Uninfected	-	ND	None	NA
27776b	RM	AT-2 SIVmac251	Uninfected	-	ND	None	NA
23053	RM	SIVmac251	1	Early Acute	Endometriosis, moderate	None	<125
30127	RM	SIVmac251	1	Early Acute	Splenomegaly, mild	None	<125
31373	RM	SIVmac251	4	Early Acute	Parathyroid Nodule	None	<125
31385	RM	SIVmac251	4	Early Acute	Gastritis	None	1.5×103
30991	RM	SIVmac251	6	Early Acute	Cervical Ectopy	None	2.3×104
31523	RM	SIVmac251	6	Early Acute	Generalized Lymphadenopathy, moderate	None	7.3×104
26222	RM	SIVmac251	7	Early Acute	Lymphadenopathy, mild; Splenomegaly, mild; Intussusception, Ileocecal	None	2.6×106
34498	RM	SIVmac251	8	Early Acute	Lymphadenopathy, generalized, marked	None	2.5×106
28013	RM	SIVmac251	9	Early Acute	Lymphadenopathy, mild; Cervical ectopy	None	2.5×106
24818	RM	SIVmac251	10	Early Acute	Lymphadenopathy, generalized, moderate-marked	None	9.9×106
24037	RM	SIVmac239	14	Late Acute	Lymphadenopathy, generalized, marked; Splenomegaly; Hepatic Lipidosis; Endometritis, mild, Chronic	None	2.3×108
27099	RM	SIVmac239	21	Late Acute	Lymphadenopathy, generalized	None	6.8×106
24225	RM	SIVmac239	28	Late Acute	No significant findings	None	1.5×106
551	RM	SIVmac239	168	Chronic/Non-AIDS	Lymphadenopathy, generalized, moderate; Lymphocytic portal inflammation, moderate multifocal; Pulmonary lymphoid hyperplasia, marked	None	1.0×106
83I	RM	SIVmac239	168	Chronic/Non-AIDS	Renal lymphofollicular inflammation, mild focal	None	1.4×106
AD09	RM	SIVmac239	161	Chronic/Non-AIDS	Lymphadenopathy, generalized, moderate; Portal hapatitis, chronic suppurative with fibrosis	None	2.7×106
AY25	RM	SIVmac239	273	Chronic/Non-AIDS	Lymphadenopathy, mild; Gastritis, minimal; Colitis, mild with mucosal hyperplasia	None	3.5×105 (30)c
AY44	RM	SIVmac239	273	Chronic/Non-AIDS	Lymphadenopathy, follicular, mild; Colitis, mild with mucosal hyperplasia; Hepatitis, mild; Nephritis, mild	None	2.0106 (55)c
R443d	RM	SIVmac239	391	Chronic/Non-AIDS	No apparent clinical manifestations of disease	ND	1.4×105
R457d	RM	SIVmac239	397	Chronic/Non-AIDS	Chronic diarrhea and recurrent epistaxis	ND	8.4×105
R462d	RM	SIVmac239	396	Chronic/Non-AIDS	Weight loss	ND	2.8×105
AY99	RM	SIVmac239	213	Chronic/AIDS	Lymphadenopathy, generalized, moderate; Gastritis, mild-moderate; Colitis; mild with multifocal lymphoid follicles; Enteritis, multifocal and focally extensive with no overt OIs.	CMV meningitis, buccal Candida	1.0×107
R451e	RM	SIVmac239	148	Chronic/AIDS	Chronic diarrhea, weight loss and cutaneous lesions; Enteritis, multifocal and focally extensive with no overt OIs.	NF	4.1×107f
R475e	RM	SIVmac239	195	Chronic/AIDS	Chronic diarrhea, intermittent epistaxis and weight loss; Enteritis, multifocal and focally extensive with no overt OIs.	NF	7.6×108
R268e	RM	SIVsmE660	56	Chronic/AIDS	Chronic diarrhea, Polyuria/Polydipsia and weight loss; Enteritis, multifocal and focally extensive with no overt OIs.	NF	1.4×109
R437e	RM	SIVsmE660	184	Chronic/AIDS	Chronic diarrhea and weight loss; Enteritis, extensive with no overt OIs.	NF	7.8×106
FOu	SM	None	Uninfected	-	NR	None	NA
FZr	SM	None	Uninfected	-	NR	None	NA
FAv	SM	SIVsmm	Naturally infected	Non-AIDS	NR	None	1.0×104g
FBn	SM	SIVsmm	Naturally infected	Non-AIDS	NR	None	3.1×104g
FBq	SM	SIVsmm	Naturally infected	Non-AIDS	NR	None	4.1×104g
FFq	SM	SIVsmm	Naturally infected	Non-AIDS	NR	None	3.5×104g
FKn	SM	SIVsmm	Naturally infected	Non-AIDS	NR	None	1.2×104g

^aViral loads are SIV vRNA copies/mL of plasma and the detection limit of this assay was 125 copies of vRNA/ml of plasma as reported previously [53]. ^bAnimal 27776 was given i.vag. aldithriol-2 (AT-2)-inactivated SIVmac239, using the same inoculation schedule as that for the other animals inoculated i.vag. with SIVmac. This animal, had no signs of infection and was considered an uninfected control. ^cViral loads measured 1 week prior being placed on an ART regimen, which lasted 5 weeks. Parentheses are viral load measurements at time of euthanasia (i.e. 5 weeks post ART). ^dPathology reports were not available for these animals, thus only major clinical findings are reported but ^ehaematoxylin and eosin stains were examined on tissues when possible. However, we did have sufficient tissue to perform large bowel histopathological evaluation, which are also reported. ^fViral load measured 4 weeks before euthanasia. ^gViral load at time of tissue biopsy. ND, not determined. NR, not relevant, NF, none found.