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. 1972 Nov;51(11):2895–2899. doi: 10.1172/JCI107113

Coproporphyrin I and III excretion in bile and urine

Neil Kaplowitz 1,2, Norman Javitt 1,2, Attallah Kappas 1,2
PMCID: PMC292439  PMID: 5080415

Abstract

The excretion of coproporphyrin isomers I and III was studied in the rat. Both isomers were found to bind equally to rat plasma and liver cytosol in vitro and to disappear from plasma at equal rates after single injections in vivo. During equimolar infusions of isomers into bile fistula animals, both the I and III isomers were excreted in bile in a concentration ratio of 2:1, respectively. Pretreatment of animals with ethinylestradiol or simultaneous infusions of phenoldibromophthalein disulfonate caused a reduction in total hepatic excretion with no change in the 2:1 ratio in bile. As hepatic excretion fell, excretion of both isomers in urine rose, with an increase in the proportion of the I isomer. The findings mimic those reported to occur in man and can be explained by inhibition of a common carrier which requires a stereospecific configuration that statistically favors the hepatic transport of the symmetrical coproporphyrin I isomer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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