Table 5.

Adverse events reported by two or more subjects through study day 56 (safety population)

Adverse Event	FG-3019 3 mg/kg (n = 14)	FG-3019 10 mg/kg (n = 10)	All (n = 24)
Overall	14 (100%)	7 (70%)	21 (88%)
Headache	3 (21%)	0	3 (13%)
AST increased	2 (14%)	0	2 (8%)
LDH increased	2 (14%)	0	2 (8%)
Herpes simplex	0	2 (20%)	2 (8%)
Fatigue	1 (7%)	1 (10%)	2 (8%)
Edema	1 (7%)	1 (10%)	2 (8%)
Excoriation	1 (7%)	1 (10%)	2 (8%)
Laceration	2 (14%)	0	2 (8%)
Pain in extremity	1 (7%)	1 (10%)	2 (8%)
Hyperglycemia	2 (14%)	0	2 (8%)
Anemia	1 (7%)	1 (10%)	2 (8%)
Anxiety	1 (7%)	1 (10%)	2 (8%)

Data presented as n (%). LDH, lactate dehydrogenase.