Table 3.
The associations between uIL-18 and uNGAL with AKI within 24 hours, 28-day mortality, receipt of acute dialysis during hospitalization within 28 days, and the composite outcome
| IL-18a |
NGALa |
|||
|---|---|---|---|---|
| ORa (95% CI) | P | ORa (95% CI) | P | |
| Outcome variable: | ||||
| AKI 24 hours (n = 64)b | 1.13 (0.75 to 1.69) | 0.554 | 1.71 (1.12 to 2.60) | 0.013 |
| Dialysis following enrollment (n = 17)c | 1.05 (0.56 to 1.98) | 0.872 | 2.76 (1.41 to 5.41) | 0.003 |
| 28-day mortality (n = 101)d | 2.02 (1.41 to 2.89) | 0.001 | 1.44 (1.00 to 2.07) | 0.052 |
| 28-day mortality or dialysis (n = 111)d | 1.86 (1.31 to 2.64) | <0.001 | 1.53 (1.07 to 2.19) | 0.020 |
a
Biomarkers were log10 transformed. Odds ratios are represented for interquartile range difference of biomarkers concentrations.
Separate logistic regression models for IL-18 and NGAL were adjusted for:
b
Enrollment age, modified APACHE II, SCr, sepsis, and ICU location.
c
Dialysis model was adjusted for APACHE II score only to avoid overfitting.
d
Enrollment age, modified APACHE II, the presence of organ failure (circulatory, coagulation, hepatic, renal), SCr, sepsis, and ICU location.