Table 4.

Effect of allopurinol in UA levels and renal function estimated by MDRD-4

	Uric Acida (mg/dl)	P1	eGFRb (ml/min per 1.73 m2)	P2
Control group
Basal	7.3 ± 1.6		39.5 ± 12.4
6 months	7.0 ± 1.6	ns	37.2 ± 14.3	ns
12 months	7.4 ± 2.0	ns	35.6 ± 13.4	ns
24 months	7.5 ± 1.7	ns	35.9 ± 12.3	ns
Allopurinol group
Basal	7.8 ± 2.1		40.8 ± 11.2
6 months	6.2 ± 1.5	0.000	41.1 ± 12.9	ns
12 months	6.0 ± 1.8	0.000	41.1 ± 13.2	ns
24 months	6.0 ± 1.2	0.000	42.2 ± 13.2	ns

^aP = 0.016 between groups.

^bP = 0.000 between groups.

P¹, differences in comparison to baseline period within each experimental group.

P², differences in comparison to baseline period within each experimental group.