Table 3.
Baseline burden of disease by patient-assessed disease severity
| Characteristic | Patient Type A(n = 35) | Patient Type B(n = 43) | Patient Type C(n = 25) | P(ANOVA) |
|---|---|---|---|---|
| Itching intensity and level of annoyance | ||||
| worst itch, night (VAS, 0 to 100) | 43.2 (28.6) | 55.3 (20.6) | 72.5 (14.1) | <0.001 |
| worst itch, day (VAS, 0 to 100) | 41.5 (28.6) | 46.7 (22.6) | 62.8 (22.3) | 0.0058 |
| worst itch, night (NRS, 0 to 10) | 4.5 (3.0) | 5.3 (2.2) | 7.2 (2.3) | <0.001 |
| worst itch, day (NRS, 0 to 10) | 4.5 (3.0) | 5.1 (2.3) | 6.5 (2.3) | 0.012 |
| how much do you itch right now? (0 to 10) | 2.8 (2.5) | 4.1 (2.6) | 5.5 (2.9) | <0.001 |
| past week, bothered by your itching (0 to 6)a | 2.2 (1.6) | 3.1 (1.2) | 4.5 (1.6) | <0.001 |
| past week, bothered by persistence or recurrence of your itching (0 to 6)a | 2.2 (1.6) | 3.1 (1.3) | 4.2 (1.8) | <0.001 |
| past week, bothered by the appearance of your skin from scratching (0 to 6)a | 1.7 (1.89) | 3.0 (1.83) | 4.3 (1.79) | <0.001 |
| Sleep disruption | ||||
| itching interfered with sleep (0 to 10) | 2.6 (3.2) | 4.3 (2.9) | 7.0 (3.0) | 0.001 |
| hours of sleep last night | 5.5 (2.2) | 4.9 (2.2) | 4.2 (2.2) | 0.0032 |
| hours of sleep lost because of itching | 1.0 (1.4) | 1.7 (1.9) | 1.9 (1.5) | 0.167 |
| MMOS sleep survey scoreb (10 to 60) | 33.3 (14.9) | 47.9 (14.2) | 58.8 (13.2) | <0.0001 |
| Mood/emotional distress | ||||
| past week, bothered by frustration about itching (0 to 6)c | 2.3 (2.1) | 3.3 (1.9) | 4.4 (1.8) | <0.001 |
| past week, bothered by being annoyed about your itching (0 to 6)c | 2.2 (1.9) | 3.8 (1.9) | 4.6 (1.8) | <0.001 |
| past week, bothered by feeling depressed about your itching (0 to 6)c | 0.9 (1.8) | 1.6 (1.5) | 3.7 (2.0) | <0.001 |
| past 24 hours, itching interfered with your enjoyment of life (0 to 10) | 1.5 (2.8) | 3.0 (3.0) | 5.5 (3.8) | <0.001 |
| Beck Depression Index total score | 8.5 (7.0) | 13.3 (10.5) | 23.4 (15.7) | <0.001 |
| Socialization/work | ||||
| past week, bothered by feeling embarrassed by your itching (0 to 6)d | 1.2 (1.8) | 1.6 (1.8) | 3.3 (2.1) | <0.001 |
| past week, bothered by the effects of your itching on interactions with others (0 to 6)d | 0.9 (1.6) | 1.8 (2.0) | 2.9 (2.1) | <0.001 |
| past week, bothered by the effects of your itching on your desire to be with people (0 to 6)d | 0.8 (1.5) | 1.4 (1.7) | 3.2 (2.1) | <0.001 |
| past week, bothered by the effect of your itching making it hard to work or do what you enjoy (0 to 6)d | 1.2 (1.9) | 1.7 (1.8) | 3.5 (2.1) | <0.001 |
| past 24 hours, itching interfered with your normal work (0 to 10) | 1.5 (2.5) | 2.7 (2.8) | 4.6 (3.6) | <0.001 |
| past 24 hours, itching interfered with your relations with other people (0 to 10) | 1.20 (2.5) | 1.95 (2.3) | 4.08 (3.3) | <0.001 |
| Composite scores | ||||
| Skindex-10 (0 to 60) | 16.8 (14.0) | 25.8 (13.8) | 39.9 (14.4) | <0.001 |
| BII (0 to 50) | 8.3 (12.0) | 14.9 (11.6) | 27.2 (14.0) | <0.001 |
Data are expressed as means (SD) or percentages. Kt/V is a measure of dialysis adequacy. Continuous variables via ANOVA with post hoc analysis of all pairwise comparisons (Tukey).
a
Skindex-10 disease domain question.
b
The value is based on the standard MMOS score SLP-9 and is based on data from visit 14 (n = 78).
c
Skindex-10 mood/emotional distress domain question.
d
Skindex-10 social functioning domain question.