Table 4.
Baseline burden of disease by pruritus intensity
| Characteristic | <50 mm | 51 to 70 mm | >71 mm | P(ANOVA) |
|---|---|---|---|---|
| Itching intensity and level of annoyance | ||||
| worst itch, night (VAS, 0 to 100 mm) | 26.7 (15.3) | 56.7 (31.0) | 76.1 (41.0) | <0.001 |
| worst itch, day (VAS, 0 to 100 mm) | 24.6 (14.5) | 48.6 (18.0) | 67.4 (23.2) | <0.001 |
| worst itch, night (NRS, 0 to 10) | 2.8 (1.7) | 5.7 (1.8) | 7.4 (2.1) | <0.001 |
| worst itch, day (NRS, 0 to 10) | 2.8 (1.9) | 5.5 (1.8) | 6.9 (2.2) | <0.001 |
| how much do you itch right now? (0 to 10) | 2.2 (2.3) | 4.3 (2.3) | 5.2 (2.8) | <0.001 |
| past week, bothered by your itching (0 to 6)a | 2.7 (1.5) | 3.9 (1.4) | 5.2 (1.1) | <0.001 |
| past week, bothered by persistence or recurrence of your itching (0 to 6)a | 2.6 (1.7) | 3.6 (1.7) | 4.8 (1.4) | <0.001 |
| past week, bothered by the appearance of your skin from scratching (0 to 6)a | 1.9 (1.9) | 2.7 (2.0) | 3.7 (2.0) | 0.001 |
| Sleep disruption | ||||
| itching interfered with sleep (0 to 10) | 1.9 (2.3) | 3,9 (2.9) | 6.6 (3.1) | <0.001 |
| hours of sleep lost because of itching | 0.8 (1.1) | 1.2 (2.1) | 2.2 (2.1) | 0.003 |
| MMOS sleep survey SLP-9b (10 to 60) | 35.4 (15.0) | 45.4 (14.6) | 55.1 (14.6) | <0.001 |
| Mood/emotional distress | ||||
| past week, bothered by frustration about itching (0 to 6)c | 2.2 (1.9) | 2.8 (2.0) | 4.3 (1.8) | <0.001 |
| past week, bothered by being annoyed about your itching (0 to 6)c | 2.3 (1.9) | 3.1 (2.1) | 4.5 (1.6) | <0.001 |
| past week, bothered by feeling depressed about your itching (0 to 6)c | 0.93 (1.4) | 1.8 (1.9) | 2.7 (2.3) | <0.001 |
| past 24 hours, itching interfered with you enjoyment of life (0 to 10) | 1.3 (2.0) | 2.3 (2.7) | 5.1 (3.9) | <0.001 |
| Beck Depression Index total score | 10.8 (8.9) | 12.7 (11.5) | 17.7 (14.3) | 0.04 |
| Socialization/work | ||||
| past week, bothered by feeling embarrassed by your itching (0 to 6)d | 0.93 (1.5) | 1.8 (1.8) | 2.7 (2.3) | <0.001 |
| past week, bothered by the effects of your itching on interactions with others (0 to 6)d | 0.7 (1.3) | 2.0 (2.0) | 2.4 (2.2) | <0.001 |
| past week, bothered by the effects of your itching on your desire to be with people (0 to 6)d | 0.6 (1.3) | 1.5 (1.7) | 2.5 (2.1) | <0.001 |
| past week, bothered by the effect of your itching making it hard to work or do what you enjoy (0 to 6)c | 0.7 (1.2) | 1.5 (1.6) | 3.3 (2.3) | <0.001 |
| past 24 hours, itching interfered with your normal work (0 to 10) | 1.0 (1.5) | 2.0 (2.3) | 4.7 (3.6) | <0.001 |
| past 24 hours, itching interfered with your relations with other people (0 to 10) | 0.7 (1.3) | 1.8 (2.4) | 3.6 (3.3) | <0.001 |
| Composite scores | ||||
| Skindex-10 (0 to 60) | 15.0 (12.2) | 24.4 (15.1) | 35.6 (14.3) | <0.001 |
| BII (0 to 50) | 6.3 (7.7) | 12.6 (11.0) | 24.9 (14.5) | <0.001 |
Data are expressed as means (SD) or percentages. Kt/V is a measure of dialysis adequacy. Continuous variables via ANOVA with post hoc analysis by all pairwise multiple comparison (Tukey).
a
Skindex-10 disease domain question.
b
The value is based on the standard MMOS score SLP-9 and is based on data from visit 14 (n = 62).
c
Skindex-10 mood/emotional distress domain question.
d
Skindex-10 social functioning domain question.