Table 5.

Responsiveness of HR-QOL measures to changes in uremic pruritus intensity

	Change from Baseline to Weeks 4, 8, and 12 in HR-QOL Scores
	BII		Skindex-10
	VAS ≥20% Worse	VAS ≥20% Better	VAS ≥20% Worse	VAS ≥20% Better
Week 4
n	10	23	10	23
mean (SD)	−3.7 (9.1)	6.7 (11.0)	−3.2 (8.0)	9.0 (11.1)
SRM	−0.40	0.61	−0.40	0.81
Week 8
n	12	15	12	15
mean (SD)	−4.5 (14.7)	6.5 (12.8)	−6.1 (5.7)	12.5 (16.1)
SRM	−0.31	0.51	−1.1	0.78
Week 12
n	20	18	20	18
mean (SD)	−5.3 (12.3)	5.9 (14.5)	−5 (8.7)	9.0 (15.5)
SRM	−0.43	0.41	−0.58	0.58

SRM is the mean change from baseline/standard deviation (SD) of the change in the score.