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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Bioorg Med Chem Lett. 2010 Jun 8;20(15):4531–4534. doi: 10.1016/j.bmcl.2010.06.029

Figure 3.

Figure 3

1530–1 interacts with Holliday junctions. All concentrations in μg/ml. (A) Dose dependent inhibition of excision SSR. Rec protein refers to inclusion of Int and Xis proteins and Integration Host Factor (IHF). (B) 1530–1 causes a shift in the migration rate of HJ DNA. The specific shift seen with 1530–1 is comparable to the shift seen in control reactions with peptide WRWYCR. (C) 1530–1 inhibits RecG-mediated unwinding of HJ DNA. RecG binds to HJs and, in the presence of ATP and Mg+2 will unwind the DNA to a replication fork. This activity is inhibited by 1530–1 in a dose dependent manner.