Figure 2. Epicardial PVAT exacerbates coronary endothelial dysfunction in MetS swine.
PVAT failed to attenuate bradykinin or sodium nitroprusside-induced vasodilation in arteries from lean-control animals (A, n = 7 and B, n = 4). In contrast, arteries from MetS swine displayed significant endothelial dysfunction that was markedly exacerbated by PVAT (C, n = 9). PVAT modestly reduced endothelial-independent vasodilation in MetS swine (D, n = 6). * P < 0.01 vs. MetS.