Figure 4.

Hair loss phenotype of Rag-2^–/– mice given splenocytes from immunized Dsg3^–/– mice. (a, b) The Rag-2^–/– mice given Dsg3^–/– splenocytes showed patchy hair loss, which first became apparent around day 15–25. (c) New hair growing in a bald area in a patchy pattern (arrows). (d) Intense in vivo IgG deposition was noticed on the cell surface of keratinocytes surrounding the telogen hair club. (e, f) Cleft formation between the cells surrounding the telogen club and the basal layer of the outer root sheath epithelium (e, arrows) and empty, dilated telogen hair follicles (f, arrows). Bars = 100 μm.