Figure 3.

Stimulation by uPA of fluid-phase endocytosis by differentiated human airway epithelia measured as uptake of Texas red–labeled dextran. (a, b) En face images (top) and confocal X-Z series (bottom) of labeled dextran uptake under basal (a) conditions and after application of 50 nM uPA (b). Dashed line indicates filter. (c) Time course of dextran uptake after application of uPA (50 nM) (d). Graph shows the effect of PI-PLC on uPA-mediated stimulation of dextran uptake. n = 10, *P < 0.05.