. Author manuscript; available in PMC: 2010 Aug 20.

Published in final edited form as: J Neurosci Res. 2007 Feb 15;85(3):673–680. doi: 10.1002/jnr.21145

TABLE II.

Quantitation of [³H] DAMGO Binding to μ-OR in METH-Sensitized Wild-Type and μ-OR Knockout Mice^†

Brain region	Dose of METH (mg/kg)	[³H] DAMGO binding (fmol/mg tissue)
Brain region	Dose of METH (mg/kg)	Wild type	μ-OR knockout
Shiatum (Bregma: 1.50 mm)	0	103.63 ± 8.46	Undetectable
	0.625	81.72 ± 5.73^*	Undetectable
	2.5	75.57 ± 16.91^*	Undetectable
	10	68.14 ± 5.11^*	Undetectable
Nucleus accumbens (Bregma: 1.50 mm)	0	134.53 ± 8.34	Undetectable
	0.625	122.21 ± 15.8	Undetectable
	2.5	111.01 ± 5.32	Undetectable
	10	101.74 ± 10.0	Undetectable

^†

Values are presented as mean ± SEM (eight mice per group). Statistical analysis was performed by one-way ANOVA, followed by Student-Newman-Keuls test.

P < 0.05 compared with the respective saline-treated group.