. Author manuscript; available in PMC: 2010 Aug 20.

Published in final edited form as: J Neurosci Res. 2007 Feb 15;85(3):673–680. doi: 10.1002/jnr.21145

TABLE III.

Quantitation of [³H]DPDPE Binding to δ-OR Binding in METH-Sensitized Wild-Type and μ-OR Knockout Mice^†

Brain region	Dose of METH (mg/kg)	[³H\| DPDPE binding (fmol/mg tissue)
Brain region	Dose of METH (mg/kg)	Wild type	μ-OR knockout
Striatum (Bregma: 1.58 mm)	0	69.69 ± 0.93	60.64 ±0.65^****
	0.625	68.01 ± 1.64	63.37 ± 0.75^*
	2.5	73.18 ± 0.53^^,^*	70.20 ± 0.30^^,^*
	10	71.36 ± 0.63^**	74.95 ± 1.09^^,^^,^**
Nucleus accumbens (Bregma: 1.58 mm)	0	73.55 ± 1.61	60.48 ± 0.91^****
	0.625	71.77 ± 1.97	63.69 ± 0.76^*
	2.5	76.62 ± 0.86^**	70.23 ± 0.76^^,^*
	10	74.84 ± 0.89	74.63 ± 1.63^^,^^,^**

^†

Values arc presented as mean ± SEM (eight mice per group). Statistical analysis was performed by two-way ANOVA, followed by Student-Newman-Keuls test.

P < 0.05 compared with the respective saline-treated group.

^**

P < 0.05 compared with the 0.625 mg/kg-treated groups.

^***

P < 0.05 compared with the 2.5 mg/kg-treated group.

^****

P < 0.05 compared with the corresponding wild-type mice.