Table 2.

Wet Weight of Whole Lungs Isolated from Saline-, SiO₂-, or TiO₂-Exposed Lymphocyte-Deficient Mice

	Wet weight (mg)
	Saline	SiO2	TiO2
C57Bl/6	35.92 ± 3.6	56.77 ± 4.6a	45.84 ± 3.2
NK-deficient	36.19 ± 2.9	60.04 ± 3.7a	38.41 ± 2.8
Rag1–/–	50.31 ± 4.4	82.18 ± 5.3a	41.31 ± 2.0
Rag1–/– (NK-depleted)	39.96 ± 3.9	81.34 ± 5.5a	43.00 ± 2.2

The left lobe was isolated from the lungs of C57Bl/6, NK-deficient, Rag1^–/–, and Rag1^–/– NK-depleted mice exposed to 25 μl saline, 1 mg SiO₂, or 0.5 mg TiO₂ (nonfibrogenic particle control), resuspended in 25 μl saline, and weighed as an indication of inflammation and edema. Results are shown as the mean ± SEM (n = 7–17 mice/exposure group). 

^aP < 0.05 compared with the respective saline control.