Fig. 5.
Cocaine and glutamate display cross-sensitization. Planarians exposed to water (W), cocaine (COC) (0.1 mM) or glutamate (GLU) twice on day 1 (60 min apart) were treated with COC (0.1 mM) or GLU (0.1 mM) on day 4. Data are expressed as mean activity counts ± S.E.M. during 1 min of drug exposure on day 4. ***p < 0.001 compared to the W/GLU group; +p < 0.05, ++p < 0.01, and +++p < 0.001 compared to the W/COC group. N = 8 planarians per group.