TABLE I.

Range of Motion and Lachman Test Among Age Groups for Untreated Animals and Animals Treated with Collagen-Platelet Composite

Variable	Juvenile*	Adolescent*	Adult*	P Value
Fat pad resected (g)
No treatment	3.3 ± 4.8	5.1 ± 3.1	5.6 ± 2.1†	0.038‡
Collagen-platelet composite	2.8 ± 2.9	5.0 ± 2.8	6.0 ± 1.7§	0.004‡
Concentration of platelets in platelet-rich plasma (×103/μL)
Collagen-platelet composite	1914 ± 140	1779 ± 140	1443 ± 177	0.138
Preop. flexion (deg)
No treatment	136.9 ± 1.7	135.0 ± 1.7	128.0 ± 2.2#	0.011‡
Collagen-platelet composite	135.0 ± 1.8	136.9 ± 1.7	125.0 ± 2.1#	<0.001‡
Preop. extension (deg)
No treatment	33.1 ± 3.2	34.4 ± 3.2	15.0 ± 4.0#	0.003‡
Collagen-platelet composite	31.3 ± 3.2	32.5 ± 3.2	15.0 ± 4.0#	0.006‡
Change in flexion (deg)
No treatment	–9.3 ± 3.8	–5.0 ± 3.5	17.0 ± 4.5#	<0.001‡
Collagen-platelet composite	–7.1 ± 4.0	–6.9 ± 3.6	24.0 ± 4.4#	<0.001‡
Change in extension (deg)
No treatment	–2.1 ± 3.8	–1.9 ± 3.5	42.0 ± 4.5#	<0.001‡
Collagen-platelet composite	1.4 ± 3.7	–1.8 ± 3.5	39.0 ± 4.5#	<0.001‡
Preop. Lachman (mm)
No treatment	2.8 ± 0.4	3.0 ± 0.4	1.2 ± 0.5#	0.022‡
Collagen-platelet composite	2.9 ± 0.4	2.8 ± 0.4	1.0 ± 0.5#	0.014‡
Lachman at 15 wks (mm)
No treatment	6.4 ± 0.8	6.3 ± 0.7	1.8 ± 0.9	<0.001‡
Collagen-platelet composite	2.3 ± 0.7**	2.8 ± 0.7**	2.0 ± 0.9	0.797

^*The data are given as the mean and the standard error of the mean.

^†Bonferroni post hoc analysis indicated p < 0.05 compared with juvenile group.

^‡Overall group differences based on repeated-measures analysis of variance with knee as a within-animal factor

^§Bonferroni post hoc analysis indicated p < 0.01 compared with juvenile group.

^#Bonferroni post hoc analysis indicated p < 0.01 compared with juvenile group and p < 0.01 compared with adolescent group.

^**Compared with no treatment, the collagen-platelet-composite effect was significant (p < 0.01).