TABLE I.
Variable | Juvenile* | Adolescent* | Adult* | P Value |
Fat pad resected (g) | ||||
No treatment | 3.3 ± 4.8 | 5.1 ± 3.1 | 5.6 ± 2.1† | 0.038‡ |
Collagen-platelet composite | 2.8 ± 2.9 | 5.0 ± 2.8 | 6.0 ± 1.7§ | 0.004‡ |
Concentration of platelets in platelet-rich plasma (×103/μL) | ||||
Collagen-platelet composite | 1914 ± 140 | 1779 ± 140 | 1443 ± 177 | 0.138 |
Preop. flexion (deg) | ||||
No treatment | 136.9 ± 1.7 | 135.0 ± 1.7 | 128.0 ± 2.2# | 0.011‡ |
Collagen-platelet composite | 135.0 ± 1.8 | 136.9 ± 1.7 | 125.0 ± 2.1# | <0.001‡ |
Preop. extension (deg) | ||||
No treatment | 33.1 ± 3.2 | 34.4 ± 3.2 | 15.0 ± 4.0# | 0.003‡ |
Collagen-platelet composite | 31.3 ± 3.2 | 32.5 ± 3.2 | 15.0 ± 4.0# | 0.006‡ |
Change in flexion (deg) | ||||
No treatment | –9.3 ± 3.8 | –5.0 ± 3.5 | 17.0 ± 4.5# | <0.001‡ |
Collagen-platelet composite | –7.1 ± 4.0 | –6.9 ± 3.6 | 24.0 ± 4.4# | <0.001‡ |
Change in extension (deg) | ||||
No treatment | –2.1 ± 3.8 | –1.9 ± 3.5 | 42.0 ± 4.5# | <0.001‡ |
Collagen-platelet composite | 1.4 ± 3.7 | –1.8 ± 3.5 | 39.0 ± 4.5# | <0.001‡ |
Preop. Lachman (mm) | ||||
No treatment | 2.8 ± 0.4 | 3.0 ± 0.4 | 1.2 ± 0.5# | 0.022‡ |
Collagen-platelet composite | 2.9 ± 0.4 | 2.8 ± 0.4 | 1.0 ± 0.5# | 0.014‡ |
Lachman at 15 wks (mm) | ||||
No treatment | 6.4 ± 0.8 | 6.3 ± 0.7 | 1.8 ± 0.9 | <0.001‡ |
Collagen-platelet composite | 2.3 ± 0.7** | 2.8 ± 0.7** | 2.0 ± 0.9 | 0.797 |
The data are given as the mean and the standard error of the mean.
Bonferroni post hoc analysis indicated p < 0.05 compared with juvenile group.
Overall group differences based on repeated-measures analysis of variance with knee as a within-animal factor
Bonferroni post hoc analysis indicated p < 0.01 compared with juvenile group.
Bonferroni post hoc analysis indicated p < 0.01 compared with juvenile group and p < 0.01 compared with adolescent group.
Compared with no treatment, the collagen-platelet-composite effect was significant (p < 0.01).