C5a receptor (C5aR, CD88) |
Neutrophils |
C5aR cleavage at the Lys18-Asp19 and Lys28-Thr29 peptide bonds by Kgp |
Suppressed neutrophil migration and activation |
(79) |
CD14 |
Human monocytes |
Reduced tumor necrosis factor-α production in response to lipopolysaccharide |
Attenuation of the cellular recognition of bacteria may help P. gingivalis to evade the host immune system and contribute to sustained chronic inflammation |
(212) |
CD14 |
Human gingival fibroblasts |
Reduced lipopolysaccharide-induced interleukin-8 production |
(214) |
CD14 |
U937 macrophage-like cells |
Suppressed tumor necrosis factor-α production in response to lipopolysaccharide |
|
(32) |
CD4 and CD8 |
Human T cells |
Decreased mitogenic response to phytohemagglutinin or concanavalin A |
Impediment of T cell functions leading to impair responses at periodontitis sites |
(97) |
CD2 and CD4 |
Human CD4+ T cells |
Decreased binding of anti-CD2 and anti-CD4 mAbs |
(238) |
Intracellular adhesion molecula-1 (ICAM-1) |
Epithelial cell lines (KB and USC) |
Hindered ICAM-1 dependent adhesion of neutrophils |
Disruption of neutrophil-oral epithelium interaction |
(213) |
Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) |
Endothelial cell monolayers |
Reduced intercellular junctional CD31 expression and gap formation |
Increased vascular permeability and neutrophil influx, enhanced local inflammation |
(239) |
CD31 |
Human neutrophils |
Removal of antiphagocytic signal (CD31) together with the generation of a novel “eat-me” signal leads to recognition of healthy neutrophils as apoptotic and their phagocytosis by macrophages |
Evasion of neutrophils antibacterial potential and effect on local inflammatory process |
(52) |
Tumor necrosis factor-α |
Fibroblasts stably trensfected with cDNA of human protumor necrosis factor-α |
Suppressed activation of NFκB and lost of ability to induce apoptosis in HL-60 cells |
Dysregulation of the cytokine network |
(121) |
CD99 |
Human endothelial cell monolayers |
Inhibition of CD99 ligation-dependent expression of leukocyte adhesion |
Hindered leukocyte recruitment to infected site |
(243) |
CD27 and CD70 |
Resting human T cells and activated B cells, respectively |
A reduction in CD27-ligation dependent co-stimulatory CD40L expression |
Downregulation of CD27/CD70-mediated lymphocytes activation |
(237) |
Thrombomodulin (TM) |
Human endothelial cell |
Reduced thrombin-dependent activation of protein C |
Promotion of vascular coagulation and inflammation |
(77) |