Table 1.
Parameter Definition
| Variable | Value | Unit | Source (Ref. no.) | |
|---|---|---|---|---|
| kon,mono | Association rate monovalent | 0.03 | L nmol−1 min−1 | 3 |
| kon,bi | Surface association rate bivalent | kon,bi = kon,mono × E | cm2 nmol−1 min−1 | 1 |
| koff | Dissociation rate | 0.3 | min−1 | 6 |
| E | Enhancement factor | 1.67 × 106 | cm−1 | 1 |
| Masstu | Tumor mass | 15–1330 g | g | 7 |
| VP | Total plasma volume | 3000 | mL | 3 |
| Vtu | Interstitial distribution volume | Masstu × 0.2 | mL | 8 |
| [Ag]s | Surface concentration of antigen | 7.9 × 10−5 | nmol cm−2 | 9 |
| Agi | Free antigens (ra or tu) | nmol | ||
| Ag0,i | Total antigens (ra or tu) | 0.25 nmol/g × Massi | nmol | |
| AgAbmono,i | Monovalently bound antibody (ra or tu) | nmol | ||
| AgAbbi,i | Bivalently bound antibody (ra or tu) | nmol | ||
| Abi | Unbound antibody of interstitial spaces in normal tissue or tumor or plasma | nmol | ||
| kin,n | Transport rate: VP to interstitial space | 0.0017 | min−1 | 10 |
| kout,n | Transport rate: interstitial space to VP | 0.005 | min−1 | 10 |
| kin,tu | Transport rate: VP to interstitial space tumor | TUI × Masstu | min−1 | 10 |
| kout,tu | Transport rate: interstitial space tumor to VP | kin,tu × VP/Vtu | min−1 | 10 |
| TUI | Tumor uptake index | 4 | mL (100 g)−1 h−1 | 4 |
| λdb | Degradation of bound antibody | 7.2 × 10−5 | min−1 | 2 |
| λdu | Degradation of unbound antibody | 3.9 × 10−4 | min−1 | 10 |
| λphy | Physical decay 111In | 1.72 × 10−4 | min−1 | 3 |
ra, readily accessible; tu, tumor.