Table 2.

Comparison of porcine and human CFTR expression patterns

	Pig		Human
Tissue	RNA	Protein	RNA		Protein
Nasal mucosa	+	+	Dupuit et al. 1995	+	Brezillon et al. 1995; Kälin et al. 1999	+
Trachea	+	+	Chow et al. 2000	+	Jacquot et al. 1993	+
Bronchi	+	+	Engelhardt et al. 1994	+	Crawford et al. 1991; Engelhardt et al. 1992	+
					Engelhardt et al. 1994	−
Lung (non-bronchial)	+	−	Mendes et al. 2004; Regnier et al. 2008	+	Regnier et al. 2008	+
Heart	+	−	Warth et al. 1996; Yajima et al. 1997	+	—	ND
Aorta	−	−	—	ND	—	ND
Esophagus	(+)	−	—	ND	—	ND
Stomach, non-glandular part	(+)	−	—	−	—	−
Stomach, glandular part	+	+	Strong et al. 1994	+	—	ND
Small intestine	+	+	Chow et al. 2000; Mendes et al. 2004	+	Kälin et al. 1999	+
Large intestine	+	+	Chow et al. 2000; Mendes et al. 2004	+	Kälin et al. 1999	+
Gall bladder	+	(+)	Tizzano et al. 1993;	+ (fetal)	Dray-Charier et al. 1995	+
			Chow et al. 2000	+
Liver	+	−	Tizzano et al. 1993;	+	Kälin et al. 1999	+
			Mendes et al. 2004	+ (fetal)
Spleen	+	−	—	ND	—	ND
Kidney	−	−	Chow et al. 2000	+	Crawford et al. 1991	+
Urinary bladder	(+)	−	—	ND	—	ND
Pancreas	(+)	(+)	Tizzano et al. 1993;	+ (fetal)	Kartner et al. 1992	+
			Chow et al. 2000	+
Salivary gland	+	(+)	Tizzano et al. 1993	+ (fetal)	Kartner et al. 1992	+
Eye	(+)	−	Sun et al. 2001	+	Wills et al. 2000	+ (fetal, cell culture)
Mandibular lymph node	−	−	—	ND	—	ND
Brain	−	−	Mulberg et al. 1998;	+	—	ND
			Chow et al. 2000	+
Pituitary gland	+	−	—	ND	—	ND
Thoracic ganglion	−	−	Niu et al. 2009	+	Niu et al. 2009	+
Skin	−	−	Mendes et al. 2004	+	Kälin et al. 1999	+
Testicle	+	−	Tizzano et al. 1994	+	Hihnala et al. 2006	+
Epididymides	+	−	Tizzano et al. 1994;	+	Hihnala et al. 2006	+
			Patrizio and Salameh 1998	+
Vas deferens/spermatic cord	−	−	Tizzano et al. 1994;	+	—	ND
			Patrizio and Salameh 1998	+
Prostate	ND	+	Tizzano et al. 1994	−	Hihnala et al. 2006	+
Uterus	+	−	Tizzano et al. 1994	+	Zheng et al. 2004	+
Ovaries	−	−	Tizzano et al. 1994	−	—	ND

+, CFTR detection; (+), weak CFTR detection; −, no CFTR detection; ND, not determined.