. Author manuscript; available in PMC: 2011 Sep 1.

Published in final edited form as: Eur J Cancer. 2010 May 24;46(13):2457–2466. doi: 10.1016/j.ejca.2010.04.020

Table 4.

Association between 4gamete defined haplotypes of APC and advanced distal colorectal adenoma risk in non-Hispanic Whites in the Prostate, Lung, Colorectal and Ovarian Screening Trial.

Haplotype	Cases %	Controls%	OR^a	95%CP^a	P^b
Block 1: rs2304793, rs2229992, rs548710, rs2909786
T-C-C-A	50.9	51.3	1.00	Ref
C-T-T-A	2.7	1.6	3.27	1.08–9.88	0.04
T-C-T-G	8.0	8.3	1.00	0.56–1.76	0.98
T-T-T-A	2.7	2.5	1.10	0.43–2.81	0.84
T-T-T-G	35.2	35.7	1.01	0.73–1.41	0.95
Block 2: rs41115, rs42427, rs459552, rs2229995
A-A-A-T	60.6	61.0	1.00	Ref
A-A-A-C	2.2	1.9	1.37	0.45–4.16	0.58
G-G-A-T	15.1	14.7	1.08	0.70–1.67	0.72
G-G-T-T	21.5	21.9	0.96	0.66–1.38	0.81

OR odds ratio, adjusted for age, sex, screening center, and race/ethnic groups; CI confidence interval

Global haplotype test (exact test) P =0.97 for all race/ethnic groups and P =0.94 for non-Hispanic Whites only.