Table 5.
APC D1822V and advanced distal colorectal adenoma risk by dietary fats and post-menopausal use, Prostate, Lung, Colon, Ovarian Screening Trial.
| Genotype | Cntrl/Case OR (95% CI) | Cntrl/Case OR (95% CI) | P interaction | ||
|---|---|---|---|---|---|
| Dietary Fats | Low ( < 66.2 g/d ) | High ( ≥ 66.2 g/d ) | |||
| rs459552 (Ex16, D1822V) | |||||
| AA | 232/214 | - | 223/248 | - | |
| AT | 118/138 | 1.22 (0.88, 1.68) | 153/113 | 0.68 (0.50, 0.94) | |
| TT | 16/18 | 1.15 (0.55, 2.37) | 15/15 | 1.01 (0.47, 2.17) | |
| AA vs. AT/TT | 1.17 (0.86, 1.60) | 0.74 (0.55, 1.00) | 0.03 | ||
| Postmenopausal Hormone Use | Never | Ever (past and Current) | |||
| rs459552 (Ex16, D1822V) | |||||
| AA | 40/47 | - | 95/88 | - | |
| AT | 27/26 | 0.76 (0.35, 1.65) | 58/57 | 1.07 (0.65, 1.76) | |
| TT | 6/4 | 0.67 (0.16, 2.84) | 5/5 | 1.09 (0.29, 4.04) | |
| AA vs. AT/TT | 0.70 (0.34, 1.42) | 1.04 (0.64, 1.70) | 0.43 | ||
a
OR odds ratio, adjusted for age, sex, screening center, and race; CI confidence interval
b
Low and high dietary intake as determined by above and below median intake in persons without adenoma.