Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
GDNF suppressed LPS-induced microglia-mediated nitric oxide production in the triple cortex-striatum-midbrain organotypic cultures (DIV16). LPS significantly increased the production of nitric oxide in a dose-dependent way. In contrast, pretreatment with GDNF attenuated nitric oxide generation (**p<0.01 or ***p<0.001 control versus LPS; ##p<0.01 LPS versus GDNF plus LPS, where n = 5/group).
