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MPA was associated with the prevention of EMT in vitro. NRK52E cells were treated with TGF-β1 (20 ng/mL), MPA (10 μM) or TGF-β1 + MPA for 48 hours. Nox-2 and α-SMA were stained in green and red in all panels and merged images are shown in panels c, f and i. TGF-β1 (d,e,f) induced Nox-2 and α-SMA costaining (*, yellow staining) in cells with pronounced features of EMT. MPA therapy was associated with prevention of typical EMT features and Nox-2 and α-SMA costaining.
