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. Author manuscript; available in PMC: 2011 Aug 20.

Published in final edited form as: Circ Res. 2010 Jun 17;107(4):501–511. doi: 10.1161/CIRCRESAHA.110.222083

(A) Atherosclerotic lesion size was measured on aortic arches from female NOR1+/+apoE−/− (n=14), NOR1+/−apoE−/− (n=15) and NOR1−/−apoE−/− (n=15) mice. Circles and triangles represent individual mice; diamonds represent medians (P < 0.05 between group, *P < 0.05 vs. NOR1+/+apoE−/−). (B) Representative aortic arches from each genotype. (C) Lipoprotein cholesterol distributions. Values represent the mean cholesterol content of each fraction (± SEM). (D-F) Sections of atherosclerotic lesions were immunostained using antisera against macrophages or VCAM-1. (D) Representative sections for macrophage staining (top) or IgG (bottom) (objective magnification ×20). (E) Macrophage accumulation was quantified in the aortic arch from NOR1+/+apoE−/− and NOR1−/−apoE−/− mice (*P < 0.05 vs. NOR1+/+apoE−/−). (F) Representative sections for VCAM-1 staining (objective magnification ×20 and ×100).

(A) Atherosclerotic lesion size was measured on aortic arches from female NOR1+/+apoE−/− (n=14), NOR1+/−apoE−/− (n=15) and NOR1−/−apoE−/− (n=15) mice. Circles and triangles represent individual mice; diamonds represent medians (P < 0.05 between group, *P < 0.05 vs. NOR1+/+apoE−/−). (B) Representative aortic arches from each genotype. (C) Lipoprotein cholesterol distributions. Values represent the mean cholesterol content of each fraction (± SEM). (D-F) Sections of atherosclerotic lesions were immunostained using antisera against macrophages or VCAM-1. (D) Representative sections for macrophage staining (top) or IgG (bottom) (objective magnification ×20). (E) Macrophage accumulation was quantified in the aortic arch from NOR1+/+apoE−/− and NOR1−/−apoE−/− mice (*P < 0.05 vs. NOR1+/+apoE−/−). (F) Representative sections for VCAM-1 staining (objective magnification ×20 and ×100).