Table 2.
Effect of hydroalcoholic extract of S. indicus on open field test in mice
| Treatment | Dose (mg/kg) | Peripheral square crossed (number) | Central square crossed (number) | Rearing (counts) | Fecal dropping (counts) | Time of immobility (sec) |
|---|---|---|---|---|---|---|
| Control | - | 28.8 ± 5.5 | 3.2 ± 1.4 | 26.3 ± 9.3 | 0.6 ± 0.4 | 15.0 ± 7.51 |
| SIE | 100 | 20.4 ± 3.71 | 2.5 ± 0.75 | 44.2 ± 10.7 | 0.3 ± 0.29 | 51.2 ± 8.81 |
| SIE | 200 | 9.2 ± 3.41* | 0.5 ± 0.47* | 48.7 ± 8.2 | 1.5 ± 0.41 | 63.4 ± 20.3* |
| SIE | 500 | 5.7 ± 2.34* | 0.8 ± 0.48* | 41.4 ± 9.8 | 1.3 ± 0.32 | 47.4 ± 7.18 |
| Diazepam | 1 | 36.2 ± 5.28 | 4.1 ± 0.49 | 5.6 ± 1.68 | 0.6 ± 0.21 | 59 ± 9.17 |
Values are expressed as mean ± SEM (n = 10). One-way ANOVA followed by Dunnett's test
*
P < 0.05 when compared with control group