Table 4.
Effect of hydroalcoholic extract of S. indicus on maximum electroshock-induced convulsions in rats
| Treatment | Dose (mg/kg) | Incidence | Phases of MES-induced seizures (sec) |
|||
|---|---|---|---|---|---|---|
| Tonic fl exion | Hind limb tonic extension | Clonic | Stupor | |||
| Control | - | 10/10 | 4.2 ± 0.42 | 9.2 ± 0.97 | 13.9 ± 2.57 | 36.1 ± 5.32 |
| SIE | 100 | 10/10 | 3.2 ± 0.31 | 9.1 ± 1.01 | 13.5 ± 2.07 | 25.3 ± 356 |
| SIE | 200 | 10/10 | 3.4 ± 0.25 | 7.6 ± 1.42 | 10.1 ± 1.09 | 31.2 ± 6.04 |
| SIE | 500 | 10/10 | 3.9 ± 0.26 | 5.3 ± 0.81* | 11.5 ± 1.49 | 25.7 ± 4.68 |
| Phenytoin | 25 | 0/10 | - | - | - | - |
Values are expressed as mean ± SEM (n = 10). One-way ANOVA followed by Dunnett's test
*
P < 0.05 when compared with control group