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Platelet counts were measured in normal nude mice that received different doses of 90Y-7G7/B6. The platelet counts were reduced in a dose-related manner. The nadir occurred at 2 weeks with recovery at 3 weeks after the administration of 90Y-7G7/B6. Three (3) of 5 mice in the 300-μCi group died approximately 2 weeks after treatment. The mice receiving 200 μCi or less of 90Y-7G7/B6 remained healthy for greater than 6 months.
