Skip to main content
. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Semin Cancer Biol. 2010 Mar 20;20(4):211–221. doi: 10.1016/j.semcancer.2010.03.001

Fig. 2. Illustration of non-LTR retrotransposon insertion mechanisms.

Fig. 2

TSDs are shown in green; AAAAA stands for polyA-tail; A) Illustrates a typical non-LTR retrotransposon insertion. These insertions are thought to occur via TPRT. The insertion is 3′ intact (contains a polyA-tail) and is flanked by TSDs. No host sequence is deleted. B) Shown are the typical hallmarks of an insertion-mediated deletion. The non-LTR retrotransposon is 3′ intact, indicated by the polyA-tail. TSDs are absent; upstream (left) of the element, host DNA is deleted. C) Illustrated is an endonuclease-independent insertion with deletion of host DNA 3′ and 5′ of the insertion. However, deletions can be limited to 3′ or 5′ host DNA sequence. The non-LTR retrotransposon usually does not contain a polyA-tail and is not flanked by TSDs.